导师风采 Supervisor's Information

Dr. Ouyang is currently an Associate Professor in the Department of Mechanical Engineering at Tsinghua University. He obtained a Ph.D. degree in Materials Science and Engineering at Tsinghua University (2017), postdoctoral training in Materials and Bioengineering at Imperial College London (2017-2020), and a visiting research training in Bioengineering at the University of Pennsylvania (2015-2016). His research interests include the design, fabrication, and application of complex biomaterial and cellular systems, with a central focus on the development of 3D bioprinting and advanced biofabrication technologies for engineering in vitro living systems. He has published a series of peer-reviewed articles in well-recognized journals, including Science Advances, Advanced Materials, Materials Today, Trends in Biotechnology, and Advanced Functional Materials, with four first-authored articles ranked as ESI Highly Cited Paper. He is currently an Associate Editor of Biomaterials Advances and the International Journal of Bioprinting, an Editorial Board Member of Biofabrication, and an Early Career Researcher committee member of ISBF. He has been recognized with a series of awards, including the ISBF New Investigator Award (2021), IOP Top Cited Author Award (2018), Distinguished Doctorate of Tsinghua University (2017), and GE Foundation TECH Award First Place (2016).

Employment

• 06/2023-present.  Associate Professor in Mechanical Engineering at Tsinghua University

• 12/2020-06/2023. Assistant Professor in Mechanical Engineering at Tsinghua University

• 08/2017-12/2020. Postdoc with Prof. Molly. M. Stevens in Materials and Bioengineering at Imperial College London

Education

• 09/2012-07/2017. PhD with Prof. Wei Sun in Materials Science and Engineering at Tsinghua University 

• 10/2015-11/2016. Visiting PhD with Prof. Jason A. Burdick in Bioengineering at the University of Pennsylvania

• 09/2008-07/2012. BEng in Mechanical Engineering at Tsinghua University

Our research interests include the design, fabrication, and application of complex biomaterial and cellular systems, with a central focus on the development of 3D bioprinting and advanced biofabrication technologies for tissue engineering and regenerative medicine. 

Topic #1: Enabling Technologies of Biofabrication (e.g., Bioprinting)

Novel approaches to the printing and assembling of living building blocks (e.g., cellular biomaterials). 

Keywords: Bottom-up (additive) manufacturing, 3D bioprinting, microfabrication, hierarchical structureT

Topic #2: Soft Biomaterials for Cell Niche Engineering (e.g., Hydrogels)

Novel biomaterials strategies to advance 3D cellular environment towards better cell-material interaction. 

Keywords: Bioinks, hydrogels, bioactive materials, microgels.

Topic #3: Applications of In Vitro Living Systems and Regenerative Medicine (e.g., Tissue Engineering) 

Practical solutions to the engineering of functional in vitro living systems towards biological function. 

Keywords: tissue engineering, organ-on-a-chip, drug testing,

Google Scholar

Book：

L. Ouyang, Study on Microextrusion-based 3D Bioprinting and Bioink Crosslinking Mechanisms (Springer, Singapore, 2019). ISBN 978-981-13-9455-3.

Selected Publications：

L. Ouyang*, J.P. Wojciechowski, J. Tang, Y. Guo, M.M. Stevens*, Tunable Microgel-Templated Porogel (MTP) Bioink for 3D Bioprinting Applications, Advanced Healthcare Materials, 11, 2200027 (2022).

L. Ouyang*, Pushing the Rheological and Mechanical Boundaries of Extrusion-based 3D Bioprinting. Trends in Biotechnology, 40, 891-902 (2022).

L. Ouyang, J.P.K. Armstrong, Y. Lin, J.P. Wojciechowski, C. Lee-Reeves, D. Hachin, K. Zhou, J.A. Burdick, M.M. Stevens*, Expanding and Optimizing 3D Bioprinting Capabilities using Complementary Network Bioinks. Science Advances, 6, eabc5529 (2020).

C. Li+, L. Ouyang+, J.P.K. Armstrong*, M.M. Stevens*, Advances in the Fabrication of Biomaterials for Gradient Tissue Engineering. Trends in Biotechnology, 10.1016/j.tibtech.2020.06.005 (2020).

L. Ouyang, J.P.K. Armstrong, M. Salmeron‐Sanchez, M.M. Stevens*, Assembling Living Building Blocks to Engineer Complex Tissues. Advanced Functional Materials 30, 1909009 (2020).

L. Ouyang, J.P.K. Armstrong, Q. Chen, Y. Lin, M.M. Stevens*, Void‐Free 3D Bioprinting for In Situ Endothelialization and Microfluidic Perfusion. Advanced Functional Materials 30, 1908349 (2020).

L. Ouyang, J.A. Burdick, W. Sun*, Facile Biofabrication of Heterogeneous Multilayer Tubular Hydrogels by Fast Diffusion-induced Gelation. ACS Applied Materials & Interfaces 10, 12424-12430 (2018).

L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick*, A Generalizable Strategy for The 3D Bioprinting of Hydrogels From Nonviscous Photo‐Crosslinkable Inks. Advanced Materials 29, 1604983 (2017).

L. Ouyang+, C.B. Highley+, C.B. Rodell, W. Sun, J.A. Burdick*, 3D Printing of Shear-thinning Hyaluronic Acid Hydrogels with Secondary Cross-linking. ACS Biomaterials Science & Engineering 2, 1743-1751 (2016).

L. Ouyang, R. Yao*, Y. Zhao, W. Sun, Effect of Bioink Properties on Printability and Cell Viability for 3D Bioplotting of Embryonic Stem Cells. Biofabrication 8, 035020 (2016).

L. Ouyang+, R. Yao+, S. Mao, X. Chen, J. Na, W. Sun*, Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation. Biofabrication 7, 044101 (2015).

L. Ouyang+, R. Yao+, X. Chen+, J. Na*, W. Sun*, 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication 7, 015010 (2015).

• ISBF New Investigator Award 2021, ISBF

• Outstanding Reviewers Award 2019, IOP

• Outstanding Reviewers Award 2018, IOP

• 3D printing solutions Poster Award, Biofabrication 2018

• Travel Award, Biofabrication 2018

• Top Cited Author Award 2018 (China), IOP

• Best Poster Award, Biofabrication 2017

• Distinguished Doctoral Dissertation, Tsinghua University, 2017. 

• Distinguished Doctorate, Tsinghua University, 2017. 

• Young Investigator Award in Mechanical Engineering, 2017. 

• GE Foundation TECH Award 2016, First Place Award. 

• National Scholarship, 2016. 

• Best Poster Award, 252nd ACS National Meeting and Exposition, 2016

• First honor BEng, Tsinghua University, 2012. 

Associate Editor, Biomaterials Advances

Associate Editor, International Journal of Bioprinting

Editorial Board Member, Biofabrication